Research

Quantum Bioelectrochemistry

Electrons navigate complex biological architectures through quantum mechanical tunneling and multi-step hopping mechanisms, bridging molecular distances to power fundamental life processes like cellular respiration and photosynthesis. To decode these intricate pathways, our approach combines real-time thermodynamic and kinetic insights from protein film voltammetry with direct single-molecule charge transport measurements via single-entity conductance, all rigorously constrained by Landauer-Marcus quantum transport modeling and structural bioinformatics. We apply this multidisciplinary methodology across diverse, high-impact bio-electronic frameworks—including multi-center redox enzymes, structural metalloproteins, charge-transmitting DNA duplexes, and novel bio-engineered artificial proteins—to establish fundamental principles for nature's electronic circuitry and inspire next-generation bio-integrated materials.

Operando bioelectrocatalysis

By combining advanced operando and in situ techniques directly with electrochemical control, our platform enables the real-time observation of redox states, structural dynamics, and catalytic function as they unfold simultaneously. We leverage a comprehensive analytical suite—including X-ray absorption spectroelectrochemistry, FTIR, EPR, circular dichroism, EC-MS, Raman, UV-Vis, and single-fiber electrochemistry—to map electronic structures, monitor conformational shifts, and track functional intermediates at molecular and single-entity resolution. 

Bioinspired Electrocatalysis

By decoding the architectural and mechanistic principles of native metalloenzymes, we design bio-inspired molecular interfaces that drive efficient energy conversion and carbon transformations. Our research bridges natural biological catalysts—such as hydrogenases, nitrogenases, and oxygen-evolving complexes—with synthetic biomimetic catalysts and custom-engineered artificial proteins to accelerate fundamental electrochemical reactions, including CO2 reduction, H2 evolution and oxidation, O2 reduction, and water oxidation. By translating structural insights, outer-sphere microenvironments, and proton-coupled electron transfer networks into solid-state electrocatalytic interfaces, we pave the way for sustainable, carbon-neutral fuel synthesis and bio-hybrid renewable energy technologies.

Bioelectronics & Diagnostic Platforms

 

We bridge fundamental interfacial mechanisms with real-world technological applications, translating molecular charge transport dynamics into responsive, high-performance diagnostic tools. By engineering custom flexible electrodes and bio-functionalized interfaces, we build integrated biosensors, point-of-care testing (POCT) platforms, and wearable bioelectronic devices capable of continuous, non-invasive molecular sensing. This translational approach transforms fundamental insights into robust, scalable devices designed for real-time health monitoring, clinical diagnostics, and adaptive bio-machine interfaces.

Sustainable Energy & Living Systems

We unite biology and materials science into a coherent framework for sustainable energy, leveraging living systems and organic architectures to power next-generation technologies. Our research spans biobatteries, organic redox batteries, and biofuel cells that convert chemical potential directly into electrical power, alongside microbial systems and engineered living materials capable of autonomous repair, sensing, and energy generation. By integrating metabolic machinery with synthetic materials, we develop self-sustaining, circular energy technologies that harmonize power demands with ecological sustainability.

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